The Centre for Maintaining Quality of Life (Planica) proposes a multi- and interdisciplinary programme of research and development, combining the expertise of clinical, university and industrial partners, with the aim of enhancing the quality of life by harnessing changes in the environment that would be beneficial to the internal environment and thus overall homeostasis. Specifically, studies will be conducted on healthy subjects and specific patient populations to elucidate the effect of hypoxia and hyperoxia on nutrition and metabolic pathways, and the ability of hyperoxia in preventing vascular and muscular deconditioning, and osteoporosis, as well as aiding post-operative rehabilitation. Technological innovations will be incorporated in new generation robotic exercising devices that would enhance rehabilitation and prevent inactivity-induced deconditioning in specific populations. A second tier research programme will develop new generation intelligent clothing systems, incorporating biomedical sensors allowing on-line monitoring of physiotherapeutical and rehabilitation procedures. The technology would also be used to develop new concepts in protective clothing for specific populations. The intelligent clothing systems would finally be matched with smart habitats for physically challenged populations. The smart habitat will incorporate a humanoid robot, together with state-of –the-art automation and environmental regulation systems. The habitat will be used to evaluate the problems and benefits of roboticised and automated habitats, as well as robot-human interactions, with the sole purpose of maintaining quality of life in elderly and physically challenged populations. All projects will be conducted with industrial partners and will provide participating SMEs with marketable protocols and prototypes.